Home > Latest News > Medical News Today: Pancreatic cancer is 'four separate diseases,' say researchers

Medical News Today: Pancreatic cancer is 'four separate diseases,' say researchers


After carrying out a detailed analysis of DNA disruption, gene expression and molecular pathways in hundreds of tumors, researchers conclude pancreatic cancer is not one but four separate diseases, each with a different genetic trigger and requiring a different treatment.
Blue DNA
The researchers found some types of pancreatic cancer have genetic mutations typically seen in colon cancer and leukemia, for which treatments are already available.

The researchers say knowing which subtypes of pancreatic cancer a patient has will allow doctors to give more accurate prognoses and treatment recommendations.

The results also raise the possibility that some types of pancreatic cancer may be treatable with drugs already in use for other cancers with similar underlying genetics.

In the journal Nature, the international team – led by Prof. Sean Grimmond of the University of Melbourne in Australia – describes how they classified pancreatic cancer into the following four subtypes:

  • Squamous
  • Pancreatic progenitor
  • Immunogenic
  • Aberrantly differentiated endocrine eXocrine (ADEX).

Prof. Grimmond, who also leads research based at the University of Glasgow in the UK, explains:

“We identified 32 genes from 10 genetic pathways that are consistently mutated in pancreatic tumors, but further analysis of gene activity revealed four distinct subtypes of tumors.”

He and his colleagues say each subtype of pancreatic cancer has different survival rates, treatments and underlying genetics.

The study addresses an urgent need to improve our understanding of the causes of pancreatic cancer – particularly at the genetic and molecular level.

Most patients with pancreatic cancer only live a few months after diagnosis and the disease is set to become the second most common cancer in westernized countries in the next 10 years.

Some suitable drugs may already be in use for other diseases

For the study, the team analyzed the genomes of 456 pancreatic tumors to identify the underlying genetic and molecular processes that go wrong inside cells when normal pancreatic tissue changes into aggressive cancer.

Cancer arises when normal cells go wrong – for example, a DNA copying error when cells divide can lead to damage inside the cell machinery. This error or mutation propagates in further divisions, giving rise to a population of faulty cells that then become tumor tissue.

The researchers made some unexpected discoveries. They found some types of pancreatic cancer have mutations typically seen in colon cancer and leukemia, for which treatments are already available.

Other types bear strong similarities to some bladder and lung cancers, says Prof. Grimmond, “and we can start to draw on that knowledge to improve treatments.”

Using an approach called “integrated genomic analysis,” the team brought together techniques that analyze not only genetic code, but also variations in structure and gene activity. This is the first time such an analysis has revealed so much about the genetic damage that leads to pancreatic cancer.

First author Dr. Peter Bailey, also based both at the University of Melbourne and the University of Glasgow, says the treatments for pancreatic cancer have not changed much in the last 20 years. There are various types of chemotherapy, but it is not very selective, “it’s like hitting the disease with a mallet with your eyes closed,” he notes.

Dr. Bailey says he and his colleagues are trying to change the clinical landscape, not only for pancreatic cancer but for all cancers. We need a better understanding of their molecular origins, he explains, so patients receive a more personalized treatment that targets the specific underlying genetic defects of their individual cancer.

Leanne Reynolds, head of research for Pancreatic Cancer UK, says:

“The findings of this research are incredibly exciting for anyone affected by pancreatic cancer, as they should mean that in the future the right patients can be given the right treatment at the right time.”

This study builds on earlier work by the team as part of the International Cancer Genome Consortium (ICGC). For example, in February 2015, Medical News Today described an earlier study, also published in Nature, that put the case for four distinct types of pancreatic cancer based on the extent of genetic disruption to chromosomes.

Source link

Check Also


A lack of essential amino acids and choline in the diet has been linked to …


Autism, cerebral palsy, multiple sclerosis: they are all incurable diseases. But there is one treatment …


Among its myriad of health benefits, fish contains nutrients that are important for developing …


A natural sugar called trehalose may trigger a cellular housekeeping process that cleans up excess …

Source link

About Basil Ita

I’m Basil Ita Ekuson, a freelancer, a blogger with a passion for research. The owner of Basil Ita mainly addresses the needs of small business owners that want to maximize their online visibility via internet marketing specifically solo ads, blogging, content marketing, SEO, social media marketing, visual marketing and affiliate marketing. Via this particular blog, I share my thoughts on HOW TO related issues, and some TIPS. My goal is to help as many people as I can to live laptop fantasy lifestyle… Feel free to drop me a line or ask me a question!

Check Also

Shocking! Man Spotted Lifting A Heavy Trolley With His Teeth In Ikeja, Lagos (Photos)

[ad_1] A Facebook user shared the photo…could that be magic or what?.. The post Shocking! ...

Leave a Reply

Your email address will not be published. Required fields are marked *