RECENTLY ADDED
Home > Latest News > Medical News Today: Gum disease bacteria linked to esophageal cancer

Medical News Today: Gum disease bacteria linked to esophageal cancer

[ad_1]

In a new study, researchers propose for the first time that Porphyromonas gingivalis – the bacterium behind gum disease – could be a risk factor for esophageal cancer.
Esophagus in neon model
The researchers found levels of P. gingivalis were significantly higher in the cancerous tissue of ESCC patients than in surrounding tissue or tissue of normal controls.

The researchers, from the University of Louisville (UofL), KY, and Henan University of Science and Technology in Luoyang, China, report their findings in the journal Infectious Agents and Cancer.

According to the Centers for Disease Control and Prevention (CDC), every year, around 15,000 people in the US are diagnosed with esophageal cancer – a cancer that starts in the esophagus or gullet, the muscular tube that moves food from the throat into the stomach.

The lining of the esophagus is made of two kinds of cell, which is why there are two main types of esophageal cancer: esophageal adenocarcinoma and esophageal squamous cell carcinoma (ESCC). ESCC is more common in developing countries.

Known risk factors for esophageal cancer include chemical exposure, diet, heredity and age – all factors already common to many other cancers.

The cancer is hard to diagnose in the early stages. For many patients, the cancer develops rapidly after diagnosis and the prognosis is not good.

For their study, the team tested tissue from 100 patients with ESCC and 30 patients who did not have the disease (the controls).

They tested samples taken from three types of esophageal tissue: cancerous tissue, non-cancerous tissue adjacent to cancerous tissue and normal tissue from the controls.

Bacterium present in 61% of cancerous tissue samples

The team found P. gingivalis was present in 61% of cancerous tissue samples and only 12% of adjacent tissue samples. They found none in the normal tissue samples.


Fast facts about esophageal cancer

  • The risk for developing esophageal cancer increases with age
  • Less than 15% of cases are in people younger than 55
  • The disease is three to four times more common in men than women.


Learn more about esophageal cancer

Co-senior author Huizhi Wang, assistant professor of oral immunology and infectious diseases at the UofL School of Dentistry, says:

“These findings provide the first direct evidence that infection could be a novel risk factor for ESCC, and may also serve as a prognostic biomarker for this type of cancer.”

He notes that if these findings are confirmed, then it could mean that eradication of a common oral bacterium could help reduce the significant number of people who develop ESCC.

To detect P. gingivalis in the tissue samples, the researchers measured expression of lysine-gingipain, an enzyme unique to the bacterium. They also looked for DNA traces of the bacterial cell.

They found levels of both the enzyme and the bacterial DNA were significantly higher in the cancerous tissue of ESCC patients than in surrounding tissue or tissue of normal controls.

The team found that levels of P. gingivalis measures were in line with levels of other measures, such as extent of cancer cell differentiation, metastasis (extent of spread) and overall survival rate.

Speculating on possible explanations, Prof. Wang offers two. Either ESCC cells are a “preferred niche” for the bacterium to thrive in, or infection with the bacterium somehow spurs the development of the cancer.

If the reason is that the cancer cells offer the bacterium a niche, then simple antibiotics could be a way forward for treatment. Another approach could be to use genetic technology to target the bacterium and ultimately eliminate the cancer cells.

Prof. Wang says should further studies actually prove that P. gingivalis causes ESCC, then the implication would be enormous, and:

“It would suggest that improving oral hygiene may reduce ESCC risk; screening for P. gingivalis in dental plaque may identify susceptible subjects; and using antibiotics or other antibacterial strategies may prevent ESCC progression.”

Meanwhile, Medical News Today recently learned about another study that shows patients with chronic kidney disease who also have severe gum disease have a higher risk of death than chronic kidney disease patients with healthy gums.

Source link




Check Also



tarantula-venom-pain-killer.jpg

Tarantula venom may be good for us after all, says research being presented at the …


stinging-nettles.jpg

Nettles, turmeric and camel milk are just a few of the herbs and foodstuffs used …


pregnant-woman-with-wine.jpg

Even a small dose of alcohol during pregnancy can increase the risk of alcoholism in …


big-brown-bat.jpg

Our ability to focus solely on relevant sensory information is a skill that we all …

[ad_2]
Source link

About Basil Ita

I’m Basil Ita Ekuson, a freelancer, a blogger with a passion for research. The owner of basilita.com. Basil Ita mainly addresses the needs of small business owners that want to maximize their online visibility via internet marketing specifically solo ads, blogging, content marketing, SEO, social media marketing, visual marketing and affiliate marketing. Via this particular blog, I share my thoughts on HOW TO related issues, and some TIPS. My goal is to help as many people as I can to live laptop fantasy lifestyle… Feel free to drop me a line or ask me a question!

Check Also

Shocking! Man Spotted Lifting A Heavy Trolley With His Teeth In Ikeja, Lagos (Photos)

[ad_1] A Facebook user shared the photo…could that be magic or what?.. The post Shocking! ...

Leave a Reply

Your email address will not be published. Required fields are marked *